Coronary artery disease is one of the leading causes of death worldwide. This year, an estimated 785,000 Americans will have a new coronary attack [1]. Treatment of coronary artery disease varies from medication alone to cardiovascular surgery. Treatment regimens depend on the number and hemodynamic significance of stenoses present. In this study, we created idealized models of stenotic coronary arteries with varying geometric properties and simulated flow and pressure in coronary stenoses using a novel computational method including a three-dimensional model of an idealized coronary artery coupled to a lumped parameter model of the heart at the inlet and a lumped parameter model of the distal coronary vasculature at the outlet.

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