Thermo-responsive hydrogel can change their swelling behavior and drug release characteristics in response to environmental temperature [1–5]. Poly(N-isopropylacrylamide) (PNIPA) hydrogel undergoes a phase transition when the temperatue is lower than a lower critical solution temperature (LCST) of ∼32°C in aqueous solution , and drug release profiles in PNIPA hydrogel can be controlled by the alternation of their solution temperatures.
- Bioengineering Division
Modified Poly (N-Isopropylacrylamide) Hydrogels for Drug Delivery
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Fu, G, & Soboyejo, W. "Modified Poly (N-Isopropylacrylamide) Hydrogels for Drug Delivery." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 605-606. ASME. https://doi.org/10.1115/SBC2010-19491
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