Although the exact cause is not clear, low back pain has been attributed to degeneration of the intervertebral disc (IVD) of the spine, which has been linked to poor nutritional supply to the disc. Because the IVD is the largest avascular structure in the human body, disc cells must rely on diffusional transport for delivery of important nutrients, such as oxygen and glucose, from the surrounding vasculature. Thus, understanding factors affecting nutritional supply to the cells is important in elucidating the etiology of disc degeneration and related back pain. While knowledge of how mechanical strain affects nutritional transport is important in understanding these phenomena, little can be found in the literature regarding strain-dependent diffusion of nutrients in human IVD.
Skip Nav Destination
ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Mechanical Compression Affects Nutritional Transport in Human Intervertebral Disc
Alicia R. Jackson,
Alicia R. Jackson
University of Miami, Coral Gables, FL
Search for other works by this author on:
Tai-Yi Yuan,
Tai-Yi Yuan
University of Miami, Coral Gables, FL
Search for other works by this author on:
Chun-Yuh Huang,
Chun-Yuh Huang
University of Miami, Coral Gables, FL
Search for other works by this author on:
Wei Yong Gu
Wei Yong Gu
University of Miami, Coral Gables, FL
Search for other works by this author on:
Alicia R. Jackson
University of Miami, Coral Gables, FL
Tai-Yi Yuan
University of Miami, Coral Gables, FL
Chun-Yuh Huang
University of Miami, Coral Gables, FL
Wei Yong Gu
University of Miami, Coral Gables, FL
Paper No:
SBC2010-19262, pp. 603-604; 2 pages
Published Online:
July 15, 2013
Citation
Jackson, AR, Yuan, T, Huang, C, & Gu, WY. "Mechanical Compression Affects Nutritional Transport in Human Intervertebral Disc." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 603-604. ASME. https://doi.org/10.1115/SBC2010-19262
Download citation file:
2
Views
Related Proceedings Papers
Related Articles
Strain-Dependent Oxygen Diffusivity in Bovine Annulus Fibrosus
J Biomech Eng (July,2009)
3D Finite Element Analysis of Nutrient Distributions and Cell Viability in the Intervertebral Disc: Effects of Deformation and Degeneration
J Biomech Eng (September,2011)
Nutrient Utilization by Bovine Articular Chondrocytes: A Combined Experimental and Theoretical Approach
J Biomech Eng (October,2005)
Related Chapters
Commercialising impedimetric biosensors: from laboratory to field
Impedimetric Biosensors for Medical Applications: Current Progress and Challenges
Introduction
Nanomaterials in Glucose Sensing: Biomedical & Nanomedical Technologies - Concise Monographs
Nanomaterials generating or enhancing glucose measuring signals
Nanomaterials in Glucose Sensing: Biomedical & Nanomedical Technologies - Concise Monographs