Among the most common models in atherosclerosis research is the atherosclerosis-prone mouse. Genetically manipulated mouse strains such as the ApoE−/− mouse will reliably form plaques under certain conditions, and these lesions have been noted to exhibit morphological and biochemical similarities with human atherosclerotic plaques. Unlike plaques in humans, however, murine plaques are not observed to rupture and form occlusive thrombi [1]. As atherosclerosis and its complications are the leading cause of death in the modern world, a comprehensive understanding of the mechanisms of plaque disruption is essential to develop diagnostic and interventional techniques. Although the mouse model is frequently employed to study plaque formation, its validity for studying plaque disruption events such as rupture or erosion has been questioned.
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ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Histological Determination of Murine Plaque Mechanics and Implications for Plaque Rupture Available to Purchase
Ian C. Campbell,
Ian C. Campbell
Georgia Institute of Technology/Emory University, Atlanta, GA
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John N. Oshinski,
John N. Oshinski
Georgia Institute of Technology/Emory University, Atlanta, GA
Emory University, Atlanta, GA
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W. Robert Taylor
W. Robert Taylor
Georgia Institute of Technology/Emory University, Atlanta, GA
Emory Univeristy, Atlanta, GA
Atlanta VA Medical Center, Decatur, GA
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Ian C. Campbell
Georgia Institute of Technology/Emory University, Atlanta, GA
Daiana Weiss
Emory University, Atlanta, GA
John N. Oshinski
Georgia Institute of Technology/Emory University, Atlanta, GA
Emory University, Atlanta, GA
W. Robert Taylor
Georgia Institute of Technology/Emory University, Atlanta, GA
Emory Univeristy, Atlanta, GA
Atlanta VA Medical Center, Decatur, GA
Paper No:
SBC2010-19295, pp. 557-558; 2 pages
Published Online:
July 15, 2013
Citation
Campbell, IC, Weiss, D, Oshinski, JN, & Taylor, WR. "Histological Determination of Murine Plaque Mechanics and Implications for Plaque Rupture." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 557-558. ASME. https://doi.org/10.1115/SBC2010-19295
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