Atherosclerotic lesions have a highly non-uniform distribution in regions of arterial branching and curvature, consistent with hemodynamic factors, in particular wall shear stress (WSS), controlling their development. The widespread and increasing use of the mouse as a model for studying atherosclerosis has encouraged investigation of the hemodynamics of the mouse aortic arch [1–3], in which previous studies have revealed areas of high and low lesion prevalence and variation in the expression of pro-atherogenic molecules [4]. Our previous computational simulations [1–2] did not produce distributions of WSS that explain the pattern of lesions. We are currently investigating whether incorporation of more realistic aortic root velocity measurements, obtained using phase-contrast magnetic resonance imaging (PC-MRI), into these simulations can improve the correlation with disease. Here we present velocities obtained by PC-MRI and preliminary simulations employing the data.
Skip Nav Destination
ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Numerical Modelling of Blood Flow in the Mouse Aortic Arch Using Inflow Velocities Obtained by Phase-Contrast MRI
Asimina Kazakidi,
Asimina Kazakidi
Imperial College London, London, UK
Search for other works by this author on:
Marzena Wylezinska,
Marzena Wylezinska
Imperial College London, London, UK
Search for other works by this author on:
Yvette Bohraus,
Yvette Bohraus
Imperial College London, London, UK
Search for other works by this author on:
Mark Van Doormaal,
Mark Van Doormaal
Imperial College London, London, UK
Search for other works by this author on:
Jordi L. Tremoleda,
Jordi L. Tremoleda
Imperial College London, London, UK
Search for other works by this author on:
Willy Gsell,
Willy Gsell
Imperial College London, London, UK
Search for other works by this author on:
Peter D. Weinberg,
Peter D. Weinberg
Imperial College London, London, UK
Search for other works by this author on:
C. Ross Ethier
C. Ross Ethier
Imperial College London, London, UK
Search for other works by this author on:
Asimina Kazakidi
Imperial College London, London, UK
Marzena Wylezinska
Imperial College London, London, UK
Yvette Bohraus
Imperial College London, London, UK
Mark Van Doormaal
Imperial College London, London, UK
Jordi L. Tremoleda
Imperial College London, London, UK
Willy Gsell
Imperial College London, London, UK
Peter D. Weinberg
Imperial College London, London, UK
C. Ross Ethier
Imperial College London, London, UK
Paper No:
SBC2010-19270, pp. 555-556; 2 pages
Published Online:
July 15, 2013
Citation
Kazakidi, A, Wylezinska, M, Bohraus, Y, Van Doormaal, M, Tremoleda, JL, Gsell, W, Weinberg, PD, & Ethier, CR. "Numerical Modelling of Blood Flow in the Mouse Aortic Arch Using Inflow Velocities Obtained by Phase-Contrast MRI." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 555-556. ASME. https://doi.org/10.1115/SBC2010-19270
Download citation file:
5
Views
Related Proceedings Papers
Related Articles
Unsteady and Three-Dimensional Simulation of Blood Flow in the Human
Aortic Arch
J Biomech Eng (August,2002)
Related Chapters
Simulation of Thai Population Migration for Epidemiological Study
International Conference on Computer and Computer Intelligence (ICCCI 2011)
Advances in the Stochastic Modeling of Constitutive Laws at Small and Finite Strains
Advances in Computers and Information in Engineering Research, Volume 2
Industrially-Relevant Multiscale Modeling of Hydrogen Assisted Degradation
International Hydrogen Conference (IHC 2012): Hydrogen-Materials Interactions