Although autologous vessel grafts are the gold standard for bypass procedures, they are limited by availability in many cases. Current synthetic grafts are not suitable for small-diameter (ID<6mm) vascular applications due to acute thrombosis. While a tissue-engineered vascular graft (TEVG), constructed by incorporating cells within a biodegradable scaffold, seems to be a possible solution to the challenge, its success greatly relies on an appropriate cell source and an efficient cellular delivery and carrier system. Terminally-differentiated vascular cells have poor self-renewal and expansion capabilities, exhibit phenotype switching in culture, and are difficult to harvest in necessary numbers, all of which represent limitations of their use in tissue engineering. Human adult mesenchymal stem cells (MSCs) exhibit multipotentiality and self-renewal capabilities, are more readily available, and therefore could overcome these limitations [1]. Pericytes closely encircle endothelial cells in capillaries. It has been shown that pericytes purified from multiple tissue types displayed multipotentiality, suggesting that they are developmental precursors of MSC [2].
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Pericyte-Based Human Tissue Engineered Vascular Grafts:
ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Pericyte-Based Human Tissue Engineered Vascular Grafts: In Vivo Feasibility Assessment
Alejandro Nieponice,
Alejandro Nieponice
University of Pittsburgh, Pittsburgh, PA
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Lorenzo Soletti,
Lorenzo Soletti
University of Pittsburgh, Pittsburgh, PA
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Burhan Gharaibeh,
Burhan Gharaibeh
University of Pittsburgh, Pittsburgh, PA
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Mihaela Crisan,
Mihaela Crisan
University of Pittsburgh, Pittsburgh, PA
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Bruno Peault,
Bruno Peault
University of Pittsburgh, Pittsburgh, PA
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Johnny Huard,
Johnny Huard
University of Pittsburgh, Pittsburgh, PA
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William R. Wagner,
William R. Wagner
University of Pittsburgh, Pittsburgh, PA
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David A. Vorp
David A. Vorp
University of Pittsburgh, Pittsburgh, PA
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Wei He
University of Pittsburgh, Pittsburgh, PA
Alejandro Nieponice
University of Pittsburgh, Pittsburgh, PA
Lorenzo Soletti
University of Pittsburgh, Pittsburgh, PA
Yi Hong
University of Pittsburgh, Pittsburgh, PA
Burhan Gharaibeh
University of Pittsburgh, Pittsburgh, PA
Mihaela Crisan
University of Pittsburgh, Pittsburgh, PA
Bruno Peault
University of Pittsburgh, Pittsburgh, PA
Johnny Huard
University of Pittsburgh, Pittsburgh, PA
William R. Wagner
University of Pittsburgh, Pittsburgh, PA
David A. Vorp
University of Pittsburgh, Pittsburgh, PA
Paper No:
SBC2010-19387, pp. 515-516; 2 pages
Published Online:
July 15, 2013
Citation
He, W, Nieponice, A, Soletti, L, Hong, Y, Gharaibeh, B, Crisan, M, Peault, B, Huard, J, Wagner, WR, & Vorp, DA. "Pericyte-Based Human Tissue Engineered Vascular Grafts: In Vivo Feasibility Assessment." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 515-516. ASME. https://doi.org/10.1115/SBC2010-19387
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