Before the explosion of genetics research in the last century, embryonic development was largely studied from a mechanical perspective. Paired with genetic advances in understanding developmental signaling pathways and induction mechanisms, an important goal for understanding morphogenesis is to discover how the genome codes for changes in the mechanical movements of the embryonic cells. After formation of the zygote, a phase of rapid mitotic cell division is followed by epithelialization resulting in a cohesive sheet of cells termed the epiblast. During the next major phase of triploblastic development called gastrulation, a group of undifferentiated cells in the epiblast moves collectively to the embryonic midline and eventually gives rise to the three primary germ layers: endoderm, mesoderm, and ectoderm. At the primitive streak—the “organizing center” in amniotes (reptiles, birds, and mammals) which delineates anterior-posterior polarity—prospective endodermal and mesodermal precursors undergo epithelial-to-mesenchymal transition (EMT), internalization, and eventually organogenesis. “It is not birth, marriage, or death, but gastrulation which is truly the most important time in your life” (Lewis Wolpert, 1986).
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ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
A Novel Biomimetic Model for Studying Mechanics of Embryonic Morphogenesis and Differentiation Available to Purchase
Julia A. Henkels,
Julia A. Henkels
Georgia Institute of Technology, Atlanta, GA
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Evan A. Zamir
Evan A. Zamir
Georgia Institute of Technology, Atlanta, GA
Search for other works by this author on:
Julia A. Henkels
Georgia Institute of Technology, Atlanta, GA
Evan A. Zamir
Georgia Institute of Technology, Atlanta, GA
Paper No:
SBC2010-19608, pp. 431-432; 2 pages
Published Online:
July 15, 2013
Citation
Henkels, JA, & Zamir, EA. "A Novel Biomimetic Model for Studying Mechanics of Embryonic Morphogenesis and Differentiation." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 431-432. ASME. https://doi.org/10.1115/SBC2010-19608
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