Sustained mechanical loading of soft tissues covering bony prominences, as experienced by bedridden and wheelchair-bound individuals, may cause skeletal muscle damage. This can result in a condition termed pressure-related deep tissue injury (DTI), a severe kind of pressure ulcer that initiates in deep tissue layers, and progresses towards the skin. Damage pathways leading to DTI can involve ischemia, ischemia/reperfusion injury, impaired lymphatic drainage, and sustained tissue deformation. Recently, we have provided evidence that in a controlled animal model, deformation is the main trigger for damage within a 2h loading period [1,2]. However, ischemia and reperfusion may play a more important role in the damage process during prolonged loading periods.
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ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Effect of Ischemia and Reperfusion on Skeletal Muscle Damage Available to Purchase
Sandra Loerakker,
Sandra Loerakker
Eindhoven University of Technology, Eindhoven, The Netherlands
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Emmy Manders,
Emmy Manders
Eindhoven University of Technology, Eindhoven, The Netherlands
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Gustav J. Strijkers,
Gustav J. Strijkers
Eindhoven University of Technology, Eindhoven, The Netherlands
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Frank P. T. Baaijens,
Frank P. T. Baaijens
Eindhoven University of Technology, Eindhoven, The Netherlands
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Dan L. Bader,
Dan L. Bader
Queen Mary, University of London, London, UK
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Klaas Nicolay,
Klaas Nicolay
Eindhoven University of Technology, Eindhoven, The Netherlands
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Cees W. J. Oomens
Cees W. J. Oomens
Eindhoven University of Technology, Eindhoven, The Netherlands
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Sandra Loerakker
Eindhoven University of Technology, Eindhoven, The Netherlands
Emmy Manders
Eindhoven University of Technology, Eindhoven, The Netherlands
Gustav J. Strijkers
Eindhoven University of Technology, Eindhoven, The Netherlands
Frank P. T. Baaijens
Eindhoven University of Technology, Eindhoven, The Netherlands
Dan L. Bader
Queen Mary, University of London, London, UK
Klaas Nicolay
Eindhoven University of Technology, Eindhoven, The Netherlands
Cees W. J. Oomens
Eindhoven University of Technology, Eindhoven, The Netherlands
Paper No:
SBC2010-19341, pp. 41-42; 2 pages
Published Online:
July 15, 2013
Citation
Loerakker, S, Manders, E, Strijkers, GJ, Baaijens, FPT, Bader, DL, Nicolay, K, & Oomens, CWJ. "Effect of Ischemia and Reperfusion on Skeletal Muscle Damage." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 41-42. ASME. https://doi.org/10.1115/SBC2010-19341
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