The mouse model offers an opportunity to investigate how alterations to the connective soft tissue contribute to the development of disease through the study of transgenic and diseased mouse strains. For example, by measuring the deformation response of the eye wall to increases in pressure of these different mouse types, the possible role of ocular tissue material properties in glaucomatous damage can be determined. Glaucoma is one of the leading causes of blindness in the United States and in the world with an estimate of 60 million people affected by this year [1]. It is caused by damage to the retinal ganglion cells (RGC), a type of neuron that transmits visual information to the brain. Despite therapeutic efforts to reduce the rate of vision loss in glaucoma patients, the rate of blindness remains high [2]. There is evidence that elevated intraocular pressure (IOP) is a strong risk factor for the disease [3–5], and it is hypothesized that possible alterations in the time-dependent scleral material properties may play an important role in cumulative RGC death.
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ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
The Inflation Response of Mouse Sclera: Age Effects on the Mechanical Properties of Scleral Tissue Available to Purchase
Kristin M. Myers,
Kristin M. Myers
Johns Hopkins University, Baltimore, MD
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Frances Cone,
Frances Cone
Johns Hopkins Medical Institute, Baltimore, MD
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Harry Quigley,
Harry Quigley
Johns Hopkins Medical Institute, Baltimore, MD
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Baptiste Coudrillier,
Baptiste Coudrillier
Johns Hopkins University, Baltimore, MD
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Thao D. Nguyen
Thao D. Nguyen
Johns Hopkins University, Baltimore, MD
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Kristin M. Myers
Johns Hopkins University, Baltimore, MD
Frances Cone
Johns Hopkins Medical Institute, Baltimore, MD
Harry Quigley
Johns Hopkins Medical Institute, Baltimore, MD
Baptiste Coudrillier
Johns Hopkins University, Baltimore, MD
Thao D. Nguyen
Johns Hopkins University, Baltimore, MD
Paper No:
SBC2010-19289, pp. 395-396; 2 pages
Published Online:
July 15, 2013
Citation
Myers, KM, Cone, F, Quigley, H, Coudrillier, B, & Nguyen, TD. "The Inflation Response of Mouse Sclera: Age Effects on the Mechanical Properties of Scleral Tissue." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 395-396. ASME. https://doi.org/10.1115/SBC2010-19289
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