Altered surface and viscoelastic material properties of mucus during respiratory diseases have a strong influence on its clearance by cilia and cough. Combined effects of the surface properties (contact angle and surface tension) and storage modulus with relatively unchanged viscosity on displacement of the simulated mucus aliquot during simulated cough through a model adult human trachea is investigated. For the mucus simulants used in this study contact angle and surface tension increase significantly as storage modulus increase while viscosity remains practically unchanged. Displacement of mucus simulant aliquots increased significantly with increasing storage modulus (and contact angle) at a given cough velocity in the range between 5 meters/second (m/s) and 30 m/s with duration 0.3 s. Results suggest that the interactive effects of elasticity and surface properties may help facilitate mucus displacement at low cough velocities.
- Bioengineering Division
Increasing Storage Modulus, Contact Angle and Surface Tension of Airway Mucus Increases Clearance by Simulated Cough Through a Model Trachea
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Ragavan, AJ, Evrensel, CA, & Krumpe, P. "Increasing Storage Modulus, Contact Angle and Surface Tension of Airway Mucus Increases Clearance by Simulated Cough Through a Model Trachea." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 261-262. ASME. https://doi.org/10.1115/SBC2010-19703
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