The outflow tract (OFT) of the chick embryonic heart offers a good model system to study the association between blood flow dynamics and cardiac morphogenesis in early heart development. At early stages, the chick heart is a looped tube without valves. The OFT, the distal region of the heart, functions as a primitive valve . The OFT is a slightly curved tube with three-layered wall (Fig. 1 (A) and (B)): the myocardium, an external muscle layer that actively contracts; the endocardium, an inner endothelial layer that directly contacts blood; in between the cardiac jelly, an extracellular matrix layer. The OFT undergoes complex morphogenesis, eventually leading to the development of semilunar valves, and this morphogenesis is sensitive to blood flow dynamics.
- Bioengineering Division
Wall Motion Influences Flow Pattern in the Outflow Tract of the Chick Embryonic Heart Tube
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Liu, A, Wang, R, Thornburg, K, & Rugonyi, S. "Wall Motion Influences Flow Pattern in the Outflow Tract of the Chick Embryonic Heart Tube." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 225-226. ASME. https://doi.org/10.1115/SBC2010-19484
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