Type I Chiari malformation (CM) is a complex disorder of the craniospinal system characterized by underdevelopment of the posterior cranial fossa and overcrowding of the normally developed hindbrain , and may be a precursor to more severe secondary disorders such as syringomyelia and hydrocephalus. Diagnosis of CM has proven to be difficult and may often take years to properly identify, as associated neurological symptoms may vary widely and overlap with symptoms of other disorders. Current methods of quantifying the severity of CM, such as radiographical measurement of the depth of hindbrain herniation into the spinal canal or measurement of posterior cranial fossa volume do not necessarily correlate to the symptom severity. Hence, there exists a need for a quantitative diagnostic method which may better characterize the severity of CM and, potentially, help neurosurgeons determine candidates for surgical treatment.
- Bioengineering Division
A Computational Study of Unsteady Resistance to Cerebrospinal Fluid Flow in Type I Chiari Malformation
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Shaffer, N, Poppe, G, Loth, F, Wieben, O, Haughton, V, & Iskandar, B. "A Computational Study of Unsteady Resistance to Cerebrospinal Fluid Flow in Type I Chiari Malformation." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 213-214. ASME. https://doi.org/10.1115/SBC2010-19642
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