Effects of wall shear stress on atherosclerotic disease are widely studied, but its effects on intracranial aneurysms are less clear. In vitro studies have demonstrated that endothelial cells (EC) go through morphological changes under abnormal wall shear stress, and these studies have also shown that abnormal wall shear stresses lead to a non-uniform EC distributions [1, 2]. Since endothelial cells play a critical role in mechanotransduction, a sub-optimal distribution of EC may affect remodeling of vessel wall.
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Endothelial Cell Migration in Patient-Specific Models of Intracranial Aneurysm
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Jou, L. "Endothelial Cell Migration in Patient-Specific Models of Intracranial Aneurysm." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 155-156. ASME. https://doi.org/10.1115/SBC2010-19027
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