Autologous vessels are the gold standard for small-diameter (<6 mm) vascular bypass; however, many patients lack suitable autologous tissues due to diseases or prior vein harvest. As an alternative, synthetic vascular grafts made from bioinert synthetic materials such as polytetrafluoroethylene (PTFE) are currently used in the medical field. The high long-term failure rate of these materials in the replacement of small vessels is known to be associated with the lack of proper signalling events by PTFE to vascular cells causing adverse hemodynamic, inflammatory or coagulatory conditions. Therefore, constant and pressing is the demand for a more biocompatible conduit with structure and function similar to native vessels. For this reason, bioresorbable scaffold constructs which can provide not only proper mechanical support, but also precise molecular cues, are desired (1). In particular, proper degradation kinetics and molecule release profiles are needed to facilitate remodeling and integration process in vivo over the time for long-term patency (2).
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ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Biomolecule-Impregnated Nanocomposite With Spatiotemporal Control Over Release and Degradation Kinetic for Vascular Engineering Available to Purchase
Walter Bonani,
Walter Bonani
University of Trento, Trento, Italy
University of Colorado at Boulder, Boulder, CO
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Antonella Motta,
Antonella Motta
University of Trento, Trento, Italy
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Claudio Migliaresi,
Claudio Migliaresi
University of Trento, Trento, Italy
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Wei Tan
Wei Tan
University of Colorado at Boulder, Boulder, CO
University of Colorado at Denver, Aurora, CO
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Walter Bonani
University of Trento, Trento, Italy
University of Colorado at Boulder, Boulder, CO
Antonella Motta
University of Trento, Trento, Italy
Claudio Migliaresi
University of Trento, Trento, Italy
Wei Tan
University of Colorado at Boulder, Boulder, CO
University of Colorado at Denver, Aurora, CO
Paper No:
SBC2010-19646, pp. 153-154; 2 pages
Published Online:
July 15, 2013
Citation
Bonani, W, Motta, A, Migliaresi, C, & Tan, W. "Biomolecule-Impregnated Nanocomposite With Spatiotemporal Control Over Release and Degradation Kinetic for Vascular Engineering." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 153-154. ASME. https://doi.org/10.1115/SBC2010-19646
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