Experimental Wall Shear Estimation as a Means of Predicting Thrombus Formation Within a 50cc Penn State Blood Pump

The use of ventricular assist devices (VADs) as a means of cardiac support for patients with diminished heart function has been investigated since the 1960s [1]. While VAD therapy has had success in assisting the failing heart, thrombus formation within these devices is one of various complications that still limit its long term use. Research has shown that thrombus deposition in VADs is a function of the underlying fluid mechanics within these devices. Areas of flow stasis, high blood residence time, and wall shear rates under 500 s⁻¹ are important flow characteristics driving thrombosis [2].