Atherosclerosis is a common cardiovascular disease, characterised by the formation of lipid rich lesions within the walls of large arteries. Onset of atherosclerosis is observed to occur in a spatially heterogeneous fashion, with lesion sites located in regions of arterial branching and high curvature. Since blood flow patterns are also spatially heterogeneous within arteries, it has been postulated that flow may play an important role in modulating atherogenesis.

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