Osteogenesis Imperfecta (OI) is a genetic disorder in collagen characterized by mechanically weakened tendon and fragile bones that affects more than 1 in 10,000 individuals. Even though many studies have attempted to associate specific mutation types with phenotypic severity, the mechanisms by which a single point mutation influences the mechanical behavior of tissues at multiple length-scales remain unknown. Here we show by a hierarchy of full atomistic and mesoscale simulation that OI mutations severely compromise the mechanical properties of collagenous tissues at multiple scales, from single molecules to collagen fibrils.
- Bioengineering Division
Osteogenesis Imperfecta: Molecular and Mesoscale Disease Mechanisms
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Gautieri, A, Uzel, S, Vesentini, S, Redaelli, A, & Buehler, MJ. "Osteogenesis Imperfecta: Molecular and Mesoscale Disease Mechanisms." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 933-934. ASME. https://doi.org/10.1115/SBC2009-204530
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