While heart valve prostheses have been used successfully since 1960, 10-year survival rates still range from 37–58% . The underlying problem with bioprostheses is a limited life from structural changes such as calcification and leaflet wear, leading to valve failure . Biological tissue fixation and methods used to mount the tissue to a supporting stent can be blamed for this shortcoming. The underlying problem with mechanical heart valves is the presence of a centrally located leaflet, or occluder. It propagates high velocity jets, turbulence and areas of stagnation: the disturbances which necessitate anticoagulation . A polyurethane valve has the potential to improve upon the shortcomings of existing valves and ultimately improve patient survival.
- Bioengineering Division
Characterization of a Novel Polymeric Trileaflet Heart Valve Prosthesis
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Corbett, SC, Verma, N, Zadeh, PB, Coskun, AU, & N.-Hashemi, H. "Characterization of a Novel Polymeric Trileaflet Heart Valve Prosthesis." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 911-912. ASME. https://doi.org/10.1115/SBC2009-203817
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