Mechanical stretch regulates many cell functions, including proliferation, apoptosis, migration and morphology that occur in response to stretch-induced changes in intracellular signaling and gene expression. We have previously reported that the temporal pattern of stretch-induced JNK activation is highly dependent on the spatiotemporal pattern of stretch that is applied. Specifically, cyclic uniaxial stretch causes a transient activation of JNK that subsides as their actin stress fibers (SFs) become oriented perpendicular to the direction of stretch, while cyclic equibiaxial stretch causes a sustained activation of JNK and does not induce SF orientation (1).

This content is only available via PDF.
You do not currently have access to this content.