It is well established that the lubricant properties play a key role in the wear of UHMWPE in prosthetic knees [1] and hips [2, 3]. The total protein concentration, the albumin – globulin ratio, the lubricant volume turnover rate, and the protein precipitation rate, all have ben found to affect the polyethylene wear rate [3]. A factor that has not yet been studied, but may be of clinical relevance, is the effect of the state of protein on the wear and friction of prosthetic joints. Protein cleavage is expected in the presence of an inflammatory response [4] and through wear processes at the articular interface. Such cleavage may have a significant effect on the lubrication regime and the wear mechanism of the prosthetic joint. An understanding of this effect is therefore required to further elucidate UHMWPE wear mechanisms, to increase the reliability and validity of wear tests for the preclinical evaluation of prosthetic joints, and to clinically assess patient effects.
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ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
Protein State Affects Wear of UHMWPE
Yasha Dwivedi,
Yasha Dwivedi
Rush University Medical Center, Chicago, IL
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Michel P. Laurent,
Michel P. Laurent
Rush University Medical Center, Chicago, IL
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Tom Schmid,
Tom Schmid
Rush University Medical Center, Chicago, IL
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Markus A. Wimmer
Markus A. Wimmer
Rush University Medical Center, Chicago, IL
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Yasha Dwivedi
Rush University Medical Center, Chicago, IL
Michel P. Laurent
Rush University Medical Center, Chicago, IL
Tom Schmid
Rush University Medical Center, Chicago, IL
Markus A. Wimmer
Rush University Medical Center, Chicago, IL
Paper No:
SBC2009-204577, pp. 783-784; 2 pages
Published Online:
July 19, 2013
Citation
Dwivedi, Y, Laurent, MP, Schmid, T, & Wimmer, MA. "Protein State Affects Wear of UHMWPE." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 783-784. ASME. https://doi.org/10.1115/SBC2009-204577
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