It is generally believed that bone remodeling is controlled by osteocytes, which act as mechanosensors and regulate the activity of osteoblast and osteoclast cells [1,2]. Osteocytes seem suitable for this function, since they are the most abundant cell type of bone and they form an extensive network of cellular processes by gap junction connections to each other, lining cells, and osteoblasts [1,3].
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Osteocytes in Bone Can Regulate the Turnover of Adjacent Mineralized Growth Plate Cartilage
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Cox, LGE, van Donkelaar, CC, van Rietbergen, B, Huiskes, R, & Ito, K. "Osteocytes in Bone Can Regulate the Turnover of Adjacent Mineralized Growth Plate Cartilage." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 53-54. ASME. https://doi.org/10.1115/SBC2009-206251
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