Estrogen depletion has been shown to cause bone loss in the proximal metaphysis of the rat tibia [1,2]. A decrease in bone volume fraction is frequently reported, yet there is little analysis in the literature related to changes in microporosities during osteoporosis. Our recent work quantifying microporosity changes due to estrogen depletion has shown an increase in the lacunar-canalicular porosity surrounding osteocytes in the proximal metaphysis of the rat tibia [3].
Volume Subject Area:
Bone Mechanics and Remodeling
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