Bisphosphonate use has expanded beyond traditional applications, such as the prevention of osteoporosis, into non-traditional pediatric low bone mass diseases including osteogenesis imperfecta (OI) [1]. Despite enthusiasm, some questions remain on the overall effectiveness and implications of long-term treatment. In the Brtl/+ mouse model for OI, bisphosphonate treatment improves bone size, but bending strength fails to increase to proportionate levels and bones remain brittle [2]. Complications associated with long-term bisphosphonate treatment have been noted in other systems [3,4] leading to a need for critical information describing local drug-cell interactions responsible for these observations. The purpose of this study was to validate a fluorescent bisphosphonate analog, far-red fluorescent pamidronate (FRFP) [5] as a biomarker of bisphosphonate deposition and retention in vivo to monitor local drug concentration in a site-specific manner.
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ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
Near-Infrared Imaging Reveals Site- and Age-Specific Localization of Bisphosphonate Delivery and Retention in Model of Osteogenesis Imperfecta
Kenneth M. Kozloff,
Kenneth M. Kozloff
University of Michigan, Ann Arbor, MI
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Leo I. Volakis,
Leo I. Volakis
University of Michigan, Ann Arbor, MI
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Michelle S. Caird
Michelle S. Caird
University of Michigan, Ann Arbor, MI
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Kenneth M. Kozloff
University of Michigan, Ann Arbor, MI
Leo I. Volakis
University of Michigan, Ann Arbor, MI
Joan C. Marini
NIH, Bethesda, MD
Michelle S. Caird
University of Michigan, Ann Arbor, MI
Paper No:
SBC2009-205344, pp. 49-50; 2 pages
Published Online:
July 19, 2013
Citation
Kozloff, KM, Volakis, LI, Marini, JC, & Caird, MS. "Near-Infrared Imaging Reveals Site- and Age-Specific Localization of Bisphosphonate Delivery and Retention in Model of Osteogenesis Imperfecta." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 49-50. ASME. https://doi.org/10.1115/SBC2009-205344
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