In recent years, mild or moderate hypothermia during which brain temperature is reduced to 30–35°C, has been proposed for clinical use as an adjunct for achieving protection from cerebral ischemia during cardiac bypass injury [Nussmeier 2002], carotid endarterectomy [Jamieson et al., 2003] and resection of extra-cranial aneurysm [Wagner and Zuccarello 2005], as well as stroke and traumatic brain injury [Marion et al., 1996; Marion 1997]. It has been shown that a reduction in brain temperature as small as 2°C substantially reduced ischemic cell damage [Clark et al., 1996], or improved significantly post-ischemic regional histopathology [Wass et al., 1995]. Most of the currently used clinical studies have examined only systemic hypothermia by whole body cooling. The major methodological drawback of this approach is slow cooling rate (∼0.5°/hour) due to the large volume of the human body and arteriovenous shunt vasoconstriction [Krieger et al., 2001; Marion et al., 1997; Schwab et al., 1998]. Whole body cooling does induce systemic complications. The systemic risks may outweigh the beneficial effects of neuro-hypothermia in the current clinical practice. Selective brain cooling which keeps the rest of body at normal temperature, on the other hand, can be used to maximize the neuroprotection of hypothermia.
Skip Nav Destination
ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
Targeted Brain Hypothermia Induced by an Interstitial Cooling Device in Human Neck: An Experimental Study
Anilchandra Attaluri,
Anilchandra Attaluri
Widener University, Chester, PA
University of Maryland Baltimore County, Baltimore, MD
Search for other works by this author on:
Liang Zhu,
Liang Zhu
University of Maryland Baltimore County, Baltimore, MD
Search for other works by this author on:
Zhongping Huang
Zhongping Huang
Widener University, Chester, PA
Search for other works by this author on:
Anilchandra Attaluri
Widener University, Chester, PA
University of Maryland Baltimore County, Baltimore, MD
Liang Zhu
University of Maryland Baltimore County, Baltimore, MD
Zhongping Huang
Widener University, Chester, PA
Paper No:
SBC2009-205558, pp. 487-488; 2 pages
Published Online:
July 19, 2013
Citation
Attaluri, A, Zhu, L, & Huang, Z. "Targeted Brain Hypothermia Induced by an Interstitial Cooling Device in Human Neck: An Experimental Study." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 487-488. ASME. https://doi.org/10.1115/SBC2009-205558
Download citation file:
8
Views
Related Proceedings Papers
Related Articles
A Nonlinear Reduced-Order Model of the Corpus Callosum Under Planar Coronal Excitation
J Biomech Eng (September,2020)
Related Chapters
Introduction
Mechanical Blood Trauma in Circulatory-Assist Devices
Human Thermal Comfort
Electromagnetic Waves and Heat Transfer: Sensitivites to Governing Variables in Everyday Life
FCM Implementation using Artificial Bee Colony Algorithm (ABC) for Segmentation of MR Brain Images
International Conference on Computer and Automation Engineering, 4th (ICCAE 2012)