Several parameters have been proposed to assess the physiologic significance of coronary lesions invasively. The purpose of the present study is to determine the effect of heart rate and percentage area stenosis on Fractional Flow Reserve (FFR), which is the ratio of mean pressure distal to stenosis over the mean proximal (aortic) pressure and Pressure Drop Coefficient (CDP), ratio of trans-stenotic pressure gradient to distal dynamic pressure. In-vivo experiments were performed on three Yorkshire pigs, to achieve the objective. It was found that increase in heart rate does have a significant effect on the coronary diagnostic parameters with increase in area stenosis.
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Influence of Heart Rate and Area Stenosis on Coronary Diagnostic Parameters in a Porcine Model
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Kolli, KK, Peelukhana, SV, Effat, M, Helmy, T, Leesar, M, Schneeberger, EW, Hand, D, Gottliebson, W, & Banerjee, RK. "Influence of Heart Rate and Area Stenosis on Coronary Diagnostic Parameters in a Porcine Model." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 465-466. ASME. https://doi.org/10.1115/SBC2009-206730
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