The complex geometry of the vascular system can induce the development of complex primary and secondary flow regimes within blood vessels. Recent literature has focused on the impact of these complex flow regimes on endothelial cells (EC), which line blood vessels, and their role on the progression of vascular disease. One such disease, atherosclerosis has been linked to the reaction of ECs to flow conditions. Atherosclerosis is often treated by stent implantation to return the vessel lumen to its native diameter. It is hypothesized that stent struts may alter the development of secondary flow within the vessel and cause re-stenosis and/or thrombosis distal to the stent.

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