The pathogenesis, progression and rupture of cerebral aneurysms are multi-factorial mechanisms that involve arterial hemodynamics, wall biomechanics, wall mechano-transduction or mechano-biology, and peri-aneurysmal environmental effects [1]. However, the interaction and relative importance of these factors remains poorly understood. Presumably, the geometrical shape and evolution of aneurysms are governed by the interaction between hemodynamic stimuli (wall shear stress) and the biological responses of the arterial wall. In order to better understand this interaction, the goal of this study was to characterize and relate the geometrical shapes of intracranial aneurysms at a single location, the posterior communicating artery (PComA), to blood flow patterns, wall shear stress (WSS), and clinical history of previous rupture.

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