In recent years, anti-angiogenic therapy has been extensively studied in both preclinical and clinical settings. Experimental studies have approved its effects on the normalization of tumor vasculature as well as the microenvironment in tumors [1]. However, little is known about how tumor microenvironment is affected by the changes in structure of vasculature or transport properties of vessels and interstitium that are associated with anti-angiogenic therapy, since the experimental data are difficult to obtain [2].

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