Microdamage formation in bone is dependent on its ultra-structural and material properties. Previous studies of probabilistic failure analysis of mineral-collagen composites have indicated that mineral modulus affects the formation of microdamage in bone [1]. Therefore, the hypothesis of this study is that mineralization influences the morphology of microdamage in bone. To test this hypothesis, bone femurs from two types of mice (C57BL/6J and C3H/HeJ) with various bone mineral density [2] were fatigued to produce microdamage and the differences of microdamage morphology were then examined. In addition, nanoindentation techniques were employed to assess the difference of mineralization between these two mice strains.

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