The deployment of stents in some arteries outside the heart has long been recognized as problematic. The use of more flexible shape memory alloy (SMA) stents has improved success rates, making stenting a more successful option than balloon angioplasty alone in peripheral arteries. However, restenosis rates are still considerably higher in peripheral arteries, such as the, femoral and popliteal, than in coronary arteries. As well as differences in dimensions, composition and material properties, peripheral arteries can be subjected to adverse mechanical environments. In addition to the pulsatile environment experienced by all arteries, some peripheral arteries experience combinations of compression, twisting and bending [1, 2]. The objective of this study is to investigate the differences between stenting in coronary and peripheral arteries with a view to determining which factors could be responsible for elevating restenosis rates. Specifically, it will be determined which, if any, of differences in (i) geometry and material properties of the arteries, (ii) the type of stent used, and (iii) the pulsatile and flexion driven mechanical environments could be responsible for either fracture of stents or higher arterial stress levels which could explain the higher rates of restenosis seen in peripheral arteries.
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ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
Why Are Rates of Restenosis Higher in Peripheral Arteries Than Coronary Arteries? A Computational Study Available to Purchase
Michael Early,
Michael Early
Trinity College Dublin, Dublin, Ireland
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Daniel J. Kelly
Daniel J. Kelly
Trinity College Dublin, Dublin, Ireland
Search for other works by this author on:
Michael Early
Trinity College Dublin, Dublin, Ireland
Daniel J. Kelly
Trinity College Dublin, Dublin, Ireland
Paper No:
SBC2009-205431, pp. 385-386; 2 pages
Published Online:
July 19, 2013
Citation
Early, M, & Kelly, DJ. "Why Are Rates of Restenosis Higher in Peripheral Arteries Than Coronary Arteries? A Computational Study." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 385-386. ASME. https://doi.org/10.1115/SBC2009-205431
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