Development of dual diagnostic and therapeutic agents for cancer with heightened sensitivity, selectivity, and lower toxicity could greatly enhance the prognosis of patients suffering from this disease. Recent work by Dr. Harry Dorn of Virginia Tech has resulted in the creation of a novel nanostructure called a carbon nanotube peapod. This structure consists of multiple TNT EMF’s (Trimetallic nitride template endohedral metallofullerenes) contained within a single-walled carbon nanotube (CNT) in the form of a peapod. Using TNT EMFs containing gadolinium, this nanostructure can achieve a 40-fold improvement in magnetic resonance imaging (MRI) contrast enhancement [1]. The CNT component of the peapod can be utilized as a hyperthermia enhancer [2] and an effective platform for drug delivery [3]. This study focuses on the use of carbon nanotube peapods (CNT peapods) to absorb near infrared light and generate therapeutic heat for tumor destruction. With sufficient heating and nanoparticle targeted delivery to tumor cells, CNT peapods can potentially induce selective hyperthermia-mediated toxicity in tumors.
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ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
Carbon Nanotube Peapod-Mediated Laser Cancer Therapy Available to Purchase
Jon Whitney,
Jon Whitney
Virginia Polytechnic Institute and State University, Blacksburg, VA
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Jianfe Zhang,
Jianfe Zhang
Virginia Polytechnic Institute and State University, Blacksburg, VA
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Harry Dorn,
Harry Dorn
Virginia Polytechnic Institute and State University, Blacksburg, VA
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Tom Campbell,
Tom Campbell
Virginia Polytechnic Institute and State University, Blacksburg, VA
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Marissa Nichole Rylander
Marissa Nichole Rylander
Virginia Polytechnic Institute and State University, Blacksburg, VA
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Jon Whitney
Virginia Polytechnic Institute and State University, Blacksburg, VA
Jianfe Zhang
Virginia Polytechnic Institute and State University, Blacksburg, VA
Harry Dorn
Virginia Polytechnic Institute and State University, Blacksburg, VA
Tom Campbell
Virginia Polytechnic Institute and State University, Blacksburg, VA
Sayan Naha
ADA Technologies, Littleton, CO
Marissa Nichole Rylander
Virginia Polytechnic Institute and State University, Blacksburg, VA
Paper No:
SBC2009-206786, pp. 355-356; 2 pages
Published Online:
July 19, 2013
Citation
Whitney, J, Zhang, J, Dorn, H, Campbell, T, Naha, S, & Rylander, MN. "Carbon Nanotube Peapod-Mediated Laser Cancer Therapy." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 355-356. ASME. https://doi.org/10.1115/SBC2009-206786
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