Enhancement in Treatment Planning for Magnetic Nanoparticle Hyperthermia: Optimization of the Heat Absorption Pattern

Magnetic nanoparticle hyperthermia has potential to achieve optimal therapeutic results due to its ability to deliver adequate heating power to irregular and/or deep-seated tumor at low magnetic field frequency and amplitude [1]. The heat generated by the particles under the application of an external alternating magnetic field is mainly due to the Néel relaxation mechanism and/or Brownian motion of the particles [2]. In clinical applications, it is very important to ensure a maximum damage to the tumor while protecting the normal tissue. The resulted heating pattern by the nanoparticle distribution in tumor is closely related to the injection parameters [3, 4].