High prevalence of osteoarthritis and poor intrinsic healing capacity of articular cartilage create a demand for cell-based strategies for cartilage repair. It is possible to tissue engineer cartilage with almost native proteoglycan content, but collagen reaches only 15% to 35% of the native content. Also its natural arcade-like structural organization is not reproduced. These drawbacks contribute to its insufficient load-bearing properties. It is generally believed that the application of mechanical loading during culturing will improve the mechanical properties. However, a suitable mechanical loading regime has not yet been established.
- Bioengineering Division
Mechanical Stimulation Enhances Collagen Synthesis in Periosteum-Derived Cartilage
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Ravetto, A, Kock, LM, van Donkelaar, CC, & Ito, K. "Mechanical Stimulation Enhances Collagen Synthesis in Periosteum-Derived Cartilage." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 313-314. ASME. https://doi.org/10.1115/SBC2009-204245
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