The porous solid matrix (SM) of articular cartilage (AC) contains glycosaminoglycans (GAGs) and collagens (COLs). GAGs provide a fixed negative charge that produces swelling and compressive resistance and the COL network produces tensile and shear resistance. The long-term goal of this study is to improve structure-function relations for characterizing AC growth and remodeling. A recent study using GAG depletion experiments suggested that GAG-COL interactions regulate tissue mechanical properties in a manner dependent on maturational stage . The objective of this study was to characterize GAG-COL interactions on viscoelastic (VE) properties for immature AC tissue. The first aim was to modify a constituent based nonlinear VE model  to study AC tissue biomechanics. The second aim was to quantify the VE response for control and GAG depleted immature AC tested in uniaxial tension (UT).
- Bioengineering Division
Nonlinear Constituent Based Viscoelastic Modeling of GAG Depletion Experiments Suggests Strong GAG-Collagen Interactions in Immature Articular Cartilage Tissue
Klisch, SM, Thomas, GC, Asanbaeva, A, Vena, P, & Sah, RL. "Nonlinear Constituent Based Viscoelastic Modeling of GAG Depletion Experiments Suggests Strong GAG-Collagen Interactions in Immature Articular Cartilage Tissue." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 277-278. ASME. https://doi.org/10.1115/SBC2009-205014
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