Non-thermal irreversible electroporation (IRE) is a new, minimally invasive, localized tissue ablation technique . The procedure uses electrodes to deliver short-length, high voltage electric pulses to destabilize a cell membrane, leading to the creation of nanopores. When the pulses are strong enough, the cell cannot repair the damage and dies . It has been shown that substantial volumes of tissue and cutaneous tumors may be ablated in a non-thermal manner using irreversible electroporation [1, 3]. In addition, this procedure may be predicted by numerical modeling, promotes an immune response, leaves the extracellular matrix intact, does not affect nerves, may be monitored in real-time, and preserves tissue vasculature [2–5].
- Bioengineering Division
Feasibility Study for Applying Irreversible Electroporation to the Treatment of Breast Cancer
Neal, RE, II, Singh, R, Torti, S, & Davalos, RV. "Feasibility Study for Applying Irreversible Electroporation to the Treatment of Breast Cancer." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 209-210. ASME. https://doi.org/10.1115/SBC2009-206732
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