Over 2 million adults in the United States are affected by atrial fibrillation (AF), a common cardiac arrhythmia that is associated with decreased survival, increased cardiovascular morbidities, and a decrease in quality of life. Atrial fibrillation can be initiated by ectopic beats originating in the myocardial sleeves surrounding the pulmonary veins [1]. Pulmonary vein (PV) isolation via radiofrequency ablation is the current gold standard for treating patients with drug-refractory AF [2]. However, cryoablation is emerging as a new minimally-invasive technique to achieve PV isolation. Cryoablation is fast gaining acceptance due to its minimal tissue disruption, decreased thrombogenicity, and reduced complications (RF can lead to low rate of pulmonary vein stenosis) [2]. One important question in regard to this technology is whether the PV lesion is transmural and circumferential and to what extent adjacent tissues are involved in the freezing process. As ice formation lends itself to image contrast in the body, we hypothesized that intraprocedural CT visualization of the iceball formation would allow us to predict the extent of the cryolesion and/or provide us with a measure of the adjacent tissue damage.
Skip Nav Destination
ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
CT Visualization and Histopathological Assessment of Cryoablation in Pulmonary Veins
Mithun M. Shenoi,
Mithun M. Shenoi
University of Minnesota, Minneapolis, MN
Search for other works by this author on:
Xiaoqing Zhang,
Xiaoqing Zhang
University of Minnesota, Minneapolis, MN
Search for other works by this author on:
Ramji T. Venkatasubramanian,
Ramji T. Venkatasubramanian
University of Minnesota, Minneapolis, MN
Search for other works by this author on:
Erin D. Grassl,
Erin D. Grassl
University of Minnesota, Minneapolis, MN
Search for other works by this author on:
Lenny George,
Lenny George
Boston Scientific - Electrophysiology, San Jose, CA
Search for other works by this author on:
Stephen Schmechel,
Stephen Schmechel
University of Minnesota, Minneapolis, MN
Search for other works by this author on:
James E. Coad,
James E. Coad
West Virginia University, Morgantown, WV
Search for other works by this author on:
John C. Bischof
John C. Bischof
University of Minnesota, Minneapolis, MN
Search for other works by this author on:
Mithun M. Shenoi
University of Minnesota, Minneapolis, MN
Xiaoqing Zhang
University of Minnesota, Minneapolis, MN
Ramji T. Venkatasubramanian
University of Minnesota, Minneapolis, MN
Erin D. Grassl
University of Minnesota, Minneapolis, MN
Lenny George
Boston Scientific - Electrophysiology, San Jose, CA
Stephen Schmechel
University of Minnesota, Minneapolis, MN
James E. Coad
West Virginia University, Morgantown, WV
John C. Bischof
University of Minnesota, Minneapolis, MN
Paper No:
SBC2009-206640, pp. 207-208; 2 pages
Published Online:
July 19, 2013
Citation
Shenoi, MM, Zhang, X, Venkatasubramanian, RT, Grassl, ED, George, L, Schmechel, S, Coad, JE, & Bischof, JC. "CT Visualization and Histopathological Assessment of Cryoablation in Pulmonary Veins." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 207-208. ASME. https://doi.org/10.1115/SBC2009-206640
Download citation file:
5
Views
0
Citations
Related Proceedings Papers
Related Articles
CT Visualization of Cryoablation in Pulmonary Veins
J. Med. Devices (June,2009)
Smooth Anatomical Models From 3D Imaging
J. Med. Devices (June,2009)
Effect of Microscale Mass Transport and Phase Change on Numerical Prediction of Freezing in Biological Tissues
J. Heat Transfer (April,2002)
Related Chapters
mDFA Human Empirical Results
Modified Detrended Fluctuation Analysis (mDFA)
Characterization and evaluation
Biocompatible Nanomaterials for Targeted and Controlled Delivery of Biomacromolecules
Experimental Studies
Nanoparticles and Brain Tumor Treatment