The abrupt closure of an artery by an occlusive thrombus is the main cause of myocardial infarcts and other thrombotic sequelae of atherosclerosis. This thrombosis is often associated with rupture of an atherosclerotic plaque [1,2]. Histology has shown that most rupture sites are also sites of increased mechanical stress [2]. It has been widely accepted that atherosclerosis leads to locally increased stresses in the region of lesions. However, validation of this hypothesis has been impeded by a lack of experimental data on the material strength of atherosclerotic tissues. Knowledge of mechanical properties of human atherosclerotic tissues is essential for understanding the rupture mechanism and also for creating more accurate computational models for predicting fatal cardiovascular events [3]. Moreover, an increased understanding of the mechanical properties of atherosclerotic tissue is important for developing greater insight into the pathophysiology of the cardiovascular system and as well as for predicting the outcome of interventional treatments such as balloon angioplasty.
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ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
Ultimate Strength of the Adventitia and Media of Human Atherosclerotic Carotid Arteries in the Axial and Circumferential Directions
Zhongzhao Teng,
Zhongzhao Teng
Worcester Polytechnic Institute, Worcester, MA
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Allen H. Hoffman,
Allen H. Hoffman
Worcester Polytechnic Institute, Worcester, MA
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Jie Zheng,
Jie Zheng
Washington University in St. Louis, St. Louis, MO
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Pamela K. Woodard,
Pamela K. Woodard
Washington University in St. Louis, St. Louis, MO
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Dalin Tang
Dalin Tang
Worcester Polytechnic Institute, Worcester, MA
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Zhongzhao Teng
Worcester Polytechnic Institute, Worcester, MA
Allen H. Hoffman
Worcester Polytechnic Institute, Worcester, MA
Jie Zheng
Washington University in St. Louis, St. Louis, MO
Pamela K. Woodard
Washington University in St. Louis, St. Louis, MO
Dalin Tang
Worcester Polytechnic Institute, Worcester, MA
Paper No:
SBC2009-204715, pp. 1301-1302; 2 pages
Published Online:
July 19, 2013
Citation
Teng, Z, Hoffman, AH, Zheng, J, Woodard, PK, & Tang, D. "Ultimate Strength of the Adventitia and Media of Human Atherosclerotic Carotid Arteries in the Axial and Circumferential Directions." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 1301-1302. ASME. https://doi.org/10.1115/SBC2009-204715
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