The delivery of therapeutic agents into the brain is impeded by the blood-brain barrier, preventing adequate treatment of diseases of the central nervous system. Convection enhanced delivery was developed as a means to deliver therapeutic agents directly into brain tissue and to transport the drugs in the extracellular space using convective flow. Poroelastic or biphasic models have been used to study the concomitant fluid transport and tissue deformation that occurs during infusion, however previous studies have been limited by the assumption of linear elasticity of the solid phase .
- Bioengineering Division
A Nonlinear Biphasic Model for Fluid Transport and Tissue Deformation During Constant Flow Rate Infusion Into Brain Tissue
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Smith, JH, & García, JJ. "A Nonlinear Biphasic Model for Fluid Transport and Tissue Deformation During Constant Flow Rate Infusion Into Brain Tissue." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 1261-1262. ASME. https://doi.org/10.1115/SBC2009-204506
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