Mucopolysaccharidosis VII (MPS VII) is a rare pediatric, hereditary disorder characterized by deficient activity of beta-glucuronidase, an enzyme that degrades chondroitin, dermatan and heparan sulfate glycosaminoglycans (GAGs) [1,2]. This deficiency leads to systemic lysosomal accumulation of GAGs, resulting in severely impaired physical and intellectual development, with patients frequently not surviving until adulthood. In the spine, the disease is characterized by poorly formed and aligned vertebral bodies, leading to high incidences of kyphosis and scoliosis [1–3].

This content is only available via PDF.
You do not currently have access to this content.