More than 57.2 million episodes of musculoskeletal injuries were recorded in 2004 in the United States, costing the US economy more than $254 billion [1, 2]. Approximately 45% of these are tendon, ligament and joint capsule related injuries [3]. Tissue engineering approaches have emerged as an attractive alternative to conventional and oftentimes ineffective treatment methods. Implanting MSC-seeded collagen tissue engineered constructs (TECs) in the central defects of patellar tendon (PT) has significantly improved repair biomechanics compared to natural healing as well as acellular repairs in the rabbit model [4, 5]. Mechanically stimulating these MSC-collagen TECs further improved repair outcome, and TEC stiffness at the time of surgery positively correlated with and predicted repair stiffness twelve weeks after surgery [6, 7]. Although these improvements were observed twelve weeks after surgery, repairs were still not strong enough to withstand forces that might arise during more strenuous activities.
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ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
Regulation of Tendon Tissue Engineered Construct Stiffness by Culture Time, Mesenchymal Stem Cells and Mechanical Stimulation
Abhishek Jain,
Abhishek Jain
University of Cincinnati, Cincinnati, OH
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Kirsten R. C. Kinneberg,
Kirsten R. C. Kinneberg
University of Cincinnati, Cincinnati, OH
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Victor S. Nirmalanandhan,
Victor S. Nirmalanandhan
Kansas University Medical Center, Kansas City, KS
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Jason T. Shearn,
Jason T. Shearn
University of Cincinnati, Cincinnati, OH
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Heather M. Powell,
Heather M. Powell
Ohio State University, Columbus, OH
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Cynthia Gooch,
Cynthia Gooch
University of Cincinnati, Cincinnati, OH
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David L. Butler
David L. Butler
University of Cincinnati, Cincinnati, OH
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Abhishek Jain
University of Cincinnati, Cincinnati, OH
Kirsten R. C. Kinneberg
University of Cincinnati, Cincinnati, OH
Victor S. Nirmalanandhan
Kansas University Medical Center, Kansas City, KS
Jason T. Shearn
University of Cincinnati, Cincinnati, OH
Heather M. Powell
Ohio State University, Columbus, OH
Cynthia Gooch
University of Cincinnati, Cincinnati, OH
David L. Butler
University of Cincinnati, Cincinnati, OH
Paper No:
SBC2009-206775, pp. 1203-1204; 2 pages
Published Online:
July 19, 2013
Citation
Jain, A, Kinneberg, KRC, Nirmalanandhan, VS, Shearn, JT, Powell, HM, Gooch, C, & Butler, DL. "Regulation of Tendon Tissue Engineered Construct Stiffness by Culture Time, Mesenchymal Stem Cells and Mechanical Stimulation." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 1203-1204. ASME. https://doi.org/10.1115/SBC2009-206775
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