Agarose and poly(ethylene-glycol) (PEG) are commonly used as scaffolds for cell and tissue engineering applications . Agarose is a natural biomaterial that is thought to be inert  and permits growing cells and tissues in a three-dimensional suspension . Gels synthesized from photoreactive poly(ethylene glycol) (PEG) macromonomers are well suited as cell carriers because they can be rapidly photopolymerized in vivo by a chain radical polymerization that is not toxic to cells, including chondrocytes. This paper explores the differences in mechanical behavior between agarose, a physically cross-linked hydrogel, and PEG, a chemically cross-linked hydrogel, to set the foundation for choosing hydrogel properties and chemistries for a desired tissue engineering application.
- Bioengineering Division
The Mechanical Behavior of Engineered Hydrogels
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Earnshaw, AL, Roberts, JJ, Nicodemus, GD, Bryant, SJ, & Ferguson, VL. "The Mechanical Behavior of Engineered Hydrogels." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 1197-1198. ASME. https://doi.org/10.1115/SBC2009-206705
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