Given mounting evidence that mechanical force is a critical parameter in the normal development and remodeling of load-bearing tissue, there is a critical need for a new class of bioreactors which can apply controlled loads/strains to tissues or engineered constructs while permitting high-powered optical accessibility. We have developed a novel bioreactor which can be mounted onto the stage of an inverted microscope which permits direct 600× observation of a perfused specimen while the specimen is held in either load or strain control. Further, the chamber has been designed to minimize free volume to reduce the cost of reagents.
Volume Subject Area:Poster Session II: Tissue Engineering
Topics:Biological tissues, Bioreactors, Design, Stress, Bearings, Microscopes
This content is only available via PDF.
Copyright © 2009 by ASME