Tremendous efforts have been made for engineering cardiac tissue for myocardial infarction therapy [1]. Various materials and forming methods have been explored, but due to the specific physiological properties of cardiac muscle tissue, challenges still exist [2]. One of those is to create biomimetic extracellular materials to support cell function and electromechanical coupling. The scaffold material should be biocompatible, biochemically stable, mechanically strong, and highly extensible, just like native heart tissue [2]. Another challenge is to create vascular networks for oxygen and nutrient supply, much as the capillaries do in natural heart tissue [3]. In this study, chitosan and collagen were chosen to fabricate cardiac constructs with channels as small as 200 μm in diameter. Several factors such as chitosan and crosslinker concentrations and coating proteins were optimized for mechanical strength and cell seeding efficiency. Engineered tissues of significant size (12 mm in diameter × 2 mm thick) were generated in vitro using this method.
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ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
Chitosan-Collagen Based Channeled Scaffold for Cardiac Tissue Engineering
Ting Zhang,
Ting Zhang
Tsinghua University, Beijing, China
Columbia University, New York, NY
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Anna Marsano,
Anna Marsano
Columbia University, New York, NY
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Robert Maidhof,
Robert Maidhof
Columbia University, New York, NY
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Yongnian Yan,
Yongnian Yan
Tsinghua University, Beijing, China
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Jiluan Pan,
Jiluan Pan
Tsinghua University, Beijing, China
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Gordana Vunjak-Novakovic
Gordana Vunjak-Novakovic
Columbia University, New York, NY
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Ting Zhang
Tsinghua University, Beijing, China
Columbia University, New York, NY
Leo Q. Wan
Columbia University, New York, NY
Anna Marsano
Columbia University, New York, NY
Robert Maidhof
Columbia University, New York, NY
Yongnian Yan
Tsinghua University, Beijing, China
Jiluan Pan
Tsinghua University, Beijing, China
Gordana Vunjak-Novakovic
Columbia University, New York, NY
Paper No:
SBC2009-206639, pp. 1191-1192; 2 pages
Published Online:
July 19, 2013
Citation
Zhang, T, Wan, LQ, Marsano, A, Maidhof, R, Yan, Y, Pan, J, & Vunjak-Novakovic, G. "Chitosan-Collagen Based Channeled Scaffold for Cardiac Tissue Engineering." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 1191-1192. ASME. https://doi.org/10.1115/SBC2009-206639
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