Permeability is defined as the ability of a fluid to pass through a porous medium. The ease of water movement is a determinant of the interstitial fluid flow-dependent viscoelastic properties of hydrated soft tissues and also modulates transport of solutes. For articular cartilage, permeability has been quantified directly via permeation experiments and indirectly by analyzing the data from stress relaxation testing under confined compression. It is unclear whether these different methods result in consistent measurements. This further complicates quantification of the effect of an experimental treatment on permeability such as the removal of sulfated glycosaminoglycans (GAGs) [1, 2]. The objective of this study was to elucidate the impact of sulfated GAGs on the permeability of articular cartilage using direct permeation versus stress relaxation testing, and to assess any differences in permeability calculated from the two test methods.
Skip Nav Destination
ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
Removal of Sulfated Glycosaminoglycans Has a Differential Effect on Permeability of Bovine Articular Cartilage as Measured by Direct Permeation and Stress Relaxation
Heath B. Henninger,
Heath B. Henninger
University of Utah, Salt Lake City, UT
Search for other works by this author on:
Clayton J. Underwood,
Clayton J. Underwood
University of Utah, Salt Lake City, UT
Search for other works by this author on:
Gerard A. Ateshian,
Gerard A. Ateshian
Columbia University, New York, NY
Search for other works by this author on:
Jeffrey A. Weiss
Jeffrey A. Weiss
University of Utah, Salt Lake City, UT
Search for other works by this author on:
Heath B. Henninger
University of Utah, Salt Lake City, UT
Clayton J. Underwood
University of Utah, Salt Lake City, UT
Gerard A. Ateshian
Columbia University, New York, NY
Jeffrey A. Weiss
University of Utah, Salt Lake City, UT
Paper No:
SBC2009-206189, pp. 119-120; 2 pages
Published Online:
July 19, 2013
Citation
Henninger, HB, Underwood, CJ, Ateshian, GA, & Weiss, JA. "Removal of Sulfated Glycosaminoglycans Has a Differential Effect on Permeability of Bovine Articular Cartilage as Measured by Direct Permeation and Stress Relaxation." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 119-120. ASME. https://doi.org/10.1115/SBC2009-206189
Download citation file:
7
Views
Related Proceedings Papers
Related Articles
A Linear Viscoelastic Biphasic Model for Soft Tissues Based on the Theory of Porous Media
J Biomech Eng (October,2001)
The Role of Flow-Independent Viscoelasticity in the Biphasic Tensile and Compressive Responses of Articular Cartilage
J Biomech Eng (October,2001)
Biphasic Creep and Stress Relaxation of Articular Cartilage in Compression: Theory and Experiments
J Biomech Eng (February,1980)
Related Chapters
Processing/Structure/Properties Relationships in Polymer Blends for the Development of Functional Polymer Foams
Advances in Multidisciplinary Engineering
Linear Viscoelasticity
Introduction to Plastics Engineering
Later Single-Cylinder Engines
Air Engines: The History, Science, and Reality of the Perfect Engine