Structural proteins often in the form of micro and nanofibers, constituting most of intra- and extracellular matrix (ECM), are the fundamental building blocks of life [1]. Recent efforts to replace diseased or damaged tissues and organs have resulted in the molecular design and genetic engineering of recombinant proteins, and the advent of new technology for fabricating structural proteins into micro-/nanofibrous scaffolds, hoping to resemble some or all the characteristics of ECM structure and function. The fabrication of such an ECM mimic may be an important step in engineering a functional tissue. To this end, we have produced a series of silk-elastin-like proteins (SELPs) [2]. Revealed by our subsequent studies, SELPs in the form of hydrogels, thin films, and microfibers, have displayed a set of outstanding biological and physical properties. In this study, electrospinning will be pursued as a mechanism for the formation of SELP nanofibers.
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ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
Electrospinning of Recombinant Protein Polymer Nanofibers
Arjun Stokes,
Arjun Stokes
University of Arizona, Tucson, AZ
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Joseph Cappello,
Joseph Cappello
Protein Polymer Technologies, Inc., San Diego, CA
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Xiaoyi Wu
Xiaoyi Wu
University of Arizona, Tucson, AZ
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Weiguo Qiu
University of Arizona, Tucson, AZ
Arjun Stokes
University of Arizona, Tucson, AZ
Joseph Cappello
Protein Polymer Technologies, Inc., San Diego, CA
Xiaoyi Wu
University of Arizona, Tucson, AZ
Paper No:
SBC2009-206352, pp. 1183-1184; 2 pages
Published Online:
July 19, 2013
Citation
Qiu, W, Stokes, A, Cappello, J, & Wu, X. "Electrospinning of Recombinant Protein Polymer Nanofibers." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 1183-1184. ASME. https://doi.org/10.1115/SBC2009-206352
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