Shear stress due to blood flow on endothelial cells elicits numerous responses including G-protein coupled receptor activation and integrin-mediated signaling. Shear-induced change in membrane fluidity has been suggested to be one of the earliest mechanosensing mechanism involved in these processes [1, 2]. Alternatively, it has been suggested that shear forces are transduced through glycocalyx directly to transmembrane proteins and cytoskeleton , with very little shear force sensed by the membrane. It is not yet clear whether physiological tensions can alter membrane fluidity significantly.
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Tension Induces Changes in Lipid Lateral Diffusion in Model Fluid-Phase Membranes
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Muddana, HS, Gullapalli, RR, & Butler, PJ. "Tension Induces Changes in Lipid Lateral Diffusion in Model Fluid-Phase Membranes." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 1171-1172. ASME. https://doi.org/10.1115/SBC2009-206867
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