A principal concern in diabetes is the increased risk of vascular disease associated with unregulated blood glucose. Endothelial cells that line the vasculature are dysfunctional in hyperglycemia. The high glucose environment promotes basement membrane protein glycation and enhanced cross-linking, which can increase stiffness and may alter endothelial cell response to strain.
- Bioengineering Division
A Cell Stretching System to Measure Endothelial Cell Cyclic Strain Response on Spatially Defined Basement Membrane
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Figueroa, DS, & Clyne, AM. "A Cell Stretching System to Measure Endothelial Cell Cyclic Strain Response on Spatially Defined Basement Membrane." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 1161-1162. ASME. https://doi.org/10.1115/SBC2009-206848
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