The cellular microtubules MTs are hollow cylinder-shaped biopolymers with inner and outer diameter of about 17 and 25 nm and length ranging from 1 to 10 μm. They are constituted by αβ-tubulins arranged in protofilaments with a head-to-tail motif . The protofilaments bind together laterally along the MT’s long axis with a slight shift generating a spiral with a pitch of 2, 3 or 4 monomers’ length (Fig.1a). The building-block of the MT, the αβ-tubulin, is a hetero-dimer made of two globular monomers, α- and β-tubulin, each of them consisting of about 450 residues with high degree of sequence similarity from the primary to the tertiary structure level .
- Bioengineering Division
Elastic Network Normal Mode Analysis for Microtubule Mechanics
Deriu, MA, Soncini, M, Orsi, M, Patel, M, Essex, JW, Montevecchi, FM, & Redaelli, A. "Elastic Network Normal Mode Analysis for Microtubule Mechanics." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 1107-1108. ASME. https://doi.org/10.1115/SBC2009-206618
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