Proper folding of the cerebral cortex is critical to normal human brain function. The mechanisms of cortical folding, however, remain incompletely understood, although they have intrigued neuroscientists for more than a century. Clearly a biomechanical problem, cortical folding has been speculated to result from stresses induced by differential or constrained growth [1]. More recently, investigators have postulated that tension in neural axons of cerebral white matter causes specific folding patterns [2]. However, it is uncertain if sustained tension exists in axons in both the developing and mature brain.

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