Coronary circulation is mainly regulated by two serial resistances, namely, epicardial stenosis and microvascular impairments, both causing abnormal coronary blood circulation . Delineation of the true severities of these diseases is important to guide clinical decision-making processes for the selection of appropriate treatment procedures . The presently used diagnostic parameters: FFR (fractional flow reserve defined as the ratio of distal to proximal hyperemic pressure) and CFR (coronary flow reserve defined as ratio of basal to hyperemic flow) , for the evaluation of severity of epicardial coronary stenosis are well established in clinical practice. On the other hand, current methods to evaluate the microcirculatory status are limited .
- Bioengineering Division
In-Vivo Evaluation of Severity of Microvascular Impairments and Epicardial Coronary Stenoses Using Fundamental Fluid Dynamics Endpoints
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Ashtekar, KD, Kim, E, Roy, AS, Helmy, TA, Effat, MA, Schneeberger, EW, Gottliebson, WM, Back, LH, & Banerjee, RK. "In-Vivo Evaluation of Severity of Microvascular Impairments and Epicardial Coronary Stenoses Using Fundamental Fluid Dynamics Endpoints." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 877-878. ASME. https://doi.org/10.1115/SBC2008-192568
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